Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET

Danielle Groves, Rory Cunnison, Andrew McMahon, Haitian Fan, Jane Sharps, Adrian Deng, Jeremy R Keown, Ervin Fodor, Nicole C Robb

bioRxiv, Cold Spring Harbor Laboratory, 2024, pp. 2024--10

Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II

Jeremy Keown, Alaa Baazaoui, Marek Sebesta, Richard Stefl, Loic Carrique, Ervin Fodor, Jonathan M Grimes

Journal of Virology, vol. 98, American Society for Microbiology 1752 N St., NW, Washington, DC, 2024, pp. e00138--24

Structure of the Nipah virus polymerase complex

Jonathan Grimes, Esra Bal{\i}k{\c{c}}{\i}, Franziska G{\"u}nl, Loic Carrique, Jeremy Keown, Ervin Fodor

2024

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation

Ecco Staller, Lo{\"\i}c Carrique, Olivia C Swann, Haitian Fan, Jeremy R Keown, Carol M Sheppard, Wendy S Barclay, Jonathan M Grimes, Ervin Fodor

Nature Communications, vol. 15, Nature Publishing Group UK London, 2024, p. 4123

A structural understanding of influenza virus genome replication

Zihan Zhu, Ervin Fodor, Jeremy R Keown

Trends in microbiology, vol. 31, Elsevier, 2023, pp. 308--319

Atomic structure of a nudivirus occlusion body protein determined from a 70-year-old crystal sample

Jeremy R Keown, Adam D Crawshaw, Jose Trincao, Lo{\"\i}c Carrique, Richard J Gildea, Sam Horrell, Anna J Warren, Danny Axford, Robin Owen, Gwyndaf Evans, others

Nature Communications, vol. 14, Nature Publishing Group UK London, 2023, p. 4160

NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli

Michael J Barnett, Jully Pinheiro, Jeremy R Keown, Jacob Biboy, Joe Gray, Ioana-Wilhelmina Lucinescu, Waldemar Vollmer, Robert P Hirt, Augusto Simoes-Barbosa, David C Goldstone

PLoS Pathogens, vol. 19, Public Library of Science San Francisco, CA USA, 2023, pp. e1011563

Protein target highlights in CASP15: Analysis of models by structure providers

Leila T Alexander, Janani Durairaj, Andriy Kryshtafovych, Luciano A Abriata, Yusupha Bayo, Gira Bhabha, C{\'e}cile Breyton, Simon G Caulton, James Chen, S{\'e}raphine Degroux, others

Proteins: Structure, Function, and Bioinformatics, vol. 91, John Wiley \& Sons, Inc. Hoboken, USA, 2023, pp. 1571--1599

Structural and biophysical characterization of the Borna disease virus 1 phosphoprotein

Jack D Whitehead, Jonathan M Grimes, Jeremy R Keown

Acta Crystallographica Section F: Structural Biology Communications, vol. 79, International Union of Crystallography, 2023, pp. 51--60

Structural characterization of the full-length Hantaan virus polymerase

Jeremy R Keown, Lo{\"\i}c Carrique, Benjamin Nilsson-Payant, Ervin Fodor, Jonathan M Grimes

bioRxiv, Cold Spring Harbor Laboratory, 2023, pp. 2023--06

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN--nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Hannah T Baddock, Sanja Brolih, Yuliana Yosaatmadja, Malitha Ratnaweera, Marcin Bielinski, Lonnie P Swift, Abimael Cruz-Migoni, Haitian Fan, Jeremy R Keown, Alexander P Walker, others

Nucleic acids research, vol. 50, Oxford University Press, 2022, pp. 1484--1500

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

Jeremy R Keown, Zihan Zhu, Lo{\"\i}c Carrique, Haitian Fan, Alexander P Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan M Grimes

Nature communications, vol. 13, Nature Publishing Group UK London, 2022, p. 251

The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a

Hana Veler, Haitian Fan, Jeremy R Keown, Jane Sharps, Marjorie Fournier, Jonathan M Grimes, Ervin Fodor

Journal of Virology, vol. 96, American Society for Microbiology 1752 N St., NW, Washington, DC, 2022, pp. e01979--21

Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins

Max Renner, Wanwisa Dejnirattisai, Lo{\"\i}c Carrique, Itziar Serna Martin, Dimple Karia, Serban L Ilca, Shu F Ho, Abhay Kotecha, Jeremy R Keown, Juthathip Mongkolsapaya, others

Nature Communications, vol. 12, Nature Publishing Group UK London, 2021, p. 1238

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory $\alpha$C helix

Michael R Oliver, Christopher R Horne, Safal Shrestha, Jeremy R Keown, Lung-Yu Liang, Samuel N Young, Jarrod J Sandow, Andrew I Webb, David C Goldstone, Isabelle S Lucet, others

Nature Communications, vol. 12, Nature Publishing Group UK London, 2021, p. 1002

Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase

Alexander P Walker, Haitian Fan, Jeremy R Keown, Jonathan M Grimes, Ervin Fodor

bioRxiv, Cold Spring Harbor Laboratory, 2021, pp. 2021--03

Structural Analysis of the Menangle Virus P Protein Reveals a Soft Boundary between Ordered and Disordered Regions

Melissa N Webby, Nicole Herr, Esther MM Bulloch, Michael Schmitz, Jeremy R Keown, David C Goldstone, Richard L Kingston

Viruses, vol. 13, MDPI, 2021, p. 1737

Structural Analysis of the Menangle Virus P Protein Reveals a Soft Boundary between Ordered and Disordered Regions. Viruses 2021, 13, 1737

MN Webby, N Herr, EMM Bulloch, M Schmitz, JR Keown, DC Goldstone, RL Kingston

s Note: MDPI stays neu-tral with regard to jurisdictional claims in~…, 2021

Structure of an H3N2 influenza virus nucleoprotein

Michael L Knight, Haitian Fan, David LV Bauer, Jonathan M Grimes, Ervin Fodor, Jeremy R Keown

Acta Crystallographica Section F: Structural Biology Communications, vol. 77, International Union of Crystallography, 2021, pp. 208--214

The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme

Alexander P Walker, Haitian Fan, Jeremy R Keown, Michael L Knight, Jonathan M Grimes, Ervin Fodor

Nucleic acids research, vol. 49, Oxford University Press, 2021, pp. 13019--13030

Host ANP32A mediates the assembly of the influenza virus replicase

Lo{\"\i}c Carrique, Haitian Fan, Alexander P Walker, Jeremy R Keown, Jane Sharps, Ecco Staller, Wendy S Barclay, Ervin Fodor, Jonathan M Grimes

Nature, vol. 587, Nature Publishing Group UK London, 2020, pp. 638--643

Parallel evolution in the emergence of highly pathogenic avian influenza A viruses

Marina Escalera-Zamudio, Michael Golden, Bernardo Gutiérrez, Julien Thézé, Jeremy Russell Keown, Loic Carrique, Thomas A Bowden, Oliver G Pybus

Nature Communications, vol. 11, Nature Publishing Group UK London, 2020, p. 5511

The RING domain of TRIM69 promotes higher-order assembly

Jeremy R Keown, Joy Yang, Moyra M Black, David C Goldstone

Acta Crystallographica Section D: Structural Biology, vol. 76, International Union of Crystallography, 2020, pp. 954--961

A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Yunyuan Sun, Jeremy R Keown, Moyra M Black, Charl{\`e}ne Raclot, Nicholas Demarais, Didier Trono, Priscilla Turelli, David C Goldstone

Journal of molecular biology, vol. 431, Academic Press, 2019, pp. 2511--2527

A method for analyzing the composition of viral nucleoprotein complexes, produced by heterologous expression in bacteria

Melissa N Webby, Matthew P Sullivan, Kavestri M Yegambaram, Mazdak Radjainia, Jeremy R Keown, Richard L Kingston

Virology, vol. 527, Academic Press, 2019, pp. 159--168

Crystal structure of protein tyrosine phosphatase-2 from Cydia pomonella granulovirus

Guangmei Huang, Michael R Oliver, Jeremy R Keown, David C Goldstone, Peter Metcalf

Acta Crystallographica Section F: Structural Biology Communications, vol. 75, International Union of Crystallography, 2019, pp. 233--238

Design, synthesis, and biological evaluation of novel indoles targeting the influenza PB2 cap binding region

David C McGowan, Wendy Balemans, Werner Embrechts, Magali Motte, Jeremy R Keown, Christophe Buyck, Jordi Corbera, Mario Funes, Laura Moreno, Ludwig Cooymans, others

Journal of medicinal chemistry, vol. 62, American Chemical Society, 2019, pp. 9680--9690

Structure of a hyperthermostable dimeric archaeal Rubisco from Hyperthermus butylicus

Rudranuj Bundela, Jeremy Keown, Serena Watkin, Frederick Grant Pearce

Acta Crystallographica Section D: Structural Biology, vol. 75, International Union of Crystallography, 2019, pp. 536--544

Structure of a hyperthermostable dimeric archaeal Rubisco from Hyperthermus butylicus

Rudranuj Bundela, Jeremy Keown, Serena Watkin, Frederick Grant Pearce

Acta Crystallographica Section D: Structural Biology, vol. 75, International Union of Crystallography, 2019, pp. 536--544

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

Haitian Fan, Alexander P Walker, Lo{\"\i}c Carrique, Jeremy R Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, others

Nature, vol. 573, Nature Publishing Group UK London, 2019, pp. 287--290

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5$\alpha$ and mammalian autophagy-related ATG8 proteins

Jeremy R Keown, Moyra M Black, Aaron Ferron, Melvyn Yap, Michael J Barnett, F Grant Pearce, Jonathan P Stoye, David C Goldstone

Journal of Biological Chemistry, vol. 293, Elsevier, 2018, pp. 18378--18386

An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

Timothy M Ryan, Jill Trewhella, James M Murphy, Jeremy R Keown, Lachlan Casey, F Grant Pearce, David C Goldstone, Kelan Chen, Zhenyao Luo, Bostjan Kobe, others

Journal of applied crystallography, vol. 51, International Union of Crystallography, 2018, pp. 97--111

Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly

Serena AJ Watkin, Jeremy R Keown, Eric Richards, David C Goldstone, Sean RA Devenish, F Grant Pearce

Biochemical Journal, vol. 475, Portland Press Ltd., 2018, pp. 137--150

The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases

Jully Pinheiro, Jacob Biboy, Waldemar Vollmer, Robert P Hirt, Jeremy R Keown, Anastasiia Artuyants, Moyra M Black, David C Goldstone, Augusto Simoes-Barbosa

MBio, vol. 9, American Society for Microbiology 1752 N St., NW, Washington, DC, 2018, pp. 10--1128

Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5$\alpha$

Jeremy R Keown, Joy X Yang, Jordan Douglas, David C Goldstone

Scientific reports, vol. 6, Nature Publishing Group UK London, 2016, p. 26837

Crystal structure of the Trim5$\alpha$ Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface

Jeremy Russell Keown, David Charles Goldstone

Journal of structural biology, vol. 195, Academic Press, 2016, pp. 282--285

Characterization of spinach ribulose-1, 5-bisphosphate carboxylase/oxygenase activase isoforms reveals hexameric assemblies with increased thermal stability

Jeremy R Keown, Frederick Grant Pearce

Biochemical Journal, vol. 464, Portland Press Ltd., 2014, pp. 413--423

Small oligomers of ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase are required for biological activity

Jeremy R Keown, Michael DW Griffin, Haydyn DT Mertens, F Grant Pearce

Journal of Biological Chemistry, vol. 288, Elsevier, 2013, pp. 20607--20615