Protease mimicry: Dissecting the ester bond crosslinking mechanics in bacterial adhesin proteins

Yuliana Yosaatmadja, Vanessa Ung, Xinlu Liu, Yixuan Zhao, Julia K. Wardega, Aria Shetty, Sophie Schoensee, Ivanhoe K. H. Leung, Jeremy R. Keown, David C. Goldstone, Edward N. Baker, Paul G. Young, Davide Mercadante, Christopher J. Squire

Protein Science, vol. 34, 2025, pp. e70238

Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET

Danielle Groves, Rory Cunnison, Andrew McMahon, Haitian Fan, Jane Sharps, Adrian Deng, Jeremy R Keown, Ervin Fodor, Nicole C Robb

Nucleic Acids Research, vol. 53, 2025 Apr, pp. gkaf351

Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II

Jeremy Keown, Alaa Baazaoui, Marek Sebesta, Richard Stefl, Loic Carrique, Ervin Fodor, Jonathan M Grimes

Journal of Virology, vol. 98, American Society for Microbiology 1752 N St., NW, Washington, DC, 2024, pp. e00138--24

Structure of the Nipah virus polymerase complex.

Esra Balıkçı, Franziska Günl, L. Carrique, J. Keown, E. Fodor, Jonathan M Grimes

EMBO Journal, 2024

Structural characterization of the full-length Hantaan virus polymerase

Jeremy R. Keown, Loïc Carrique, Benjamin E. Nilsson-Payant, Ervin Fodor, Jonathan M. Grimes

PLOS Pathogens, vol. 20, Public Library of Science, 2024 Dec, pp. 1-18

A structural understanding of influenza virus genome replication

Zihan Zhu, Ervin Fodor, Jeremy R Keown

Trends in microbiology, vol. 31, Elsevier, 2023, pp. 308--319

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN--nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Hannah T Baddock, Sanja Brolih, Yuliana Yosaatmadja, Malitha Ratnaweera, Marcin Bielinski, Lonnie P Swift, Abimael Cruz-Migoni, Haitian Fan, Jeremy R Keown, Alexander P Walker, others

Nucleic acids research, vol. 50, Oxford University Press, 2022, pp. 1484--1500

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

Jeremy R Keown, Zihan Zhu, Lo{\"\i}c Carrique, Haitian Fan, Alexander P Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan M Grimes

Nature communications, vol. 13, Nature Publishing Group UK London, 2022, p. 251

The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a

Hana Veler, Haitian Fan, Jeremy R Keown, Jane Sharps, Marjorie Fournier, Jonathan M Grimes, Ervin Fodor

Journal of Virology, vol. 96, American Society for Microbiology 1752 N St., NW, Washington, DC, 2022, pp. e01979--21

Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins

Max Renner, Wanwisa Dejnirattisai, Lo{\"\i}c Carrique, Itziar Serna Martin, Dimple Karia, Serban L Ilca, Shu F Ho, Abhay Kotecha, Jeremy R Keown, Juthathip Mongkolsapaya, others

Nature Communications, vol. 12, Nature Publishing Group UK London, 2021, p. 1238

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory $\alpha$C helix

Michael R Oliver, Christopher R Horne, Safal Shrestha, Jeremy R Keown, Lung-Yu Liang, Samuel N Young, Jarrod J Sandow, Andrew I Webb, David C Goldstone, Isabelle S Lucet, others

Nature Communications, vol. 12, Nature Publishing Group UK London, 2021, p. 1002

Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase

Alexander P Walker, Haitian Fan, Jeremy R Keown, Jonathan M Grimes, Ervin Fodor

bioRxiv, Cold Spring Harbor Laboratory, 2021, pp. 2021--03

Structural Analysis of the Menangle Virus P Protein Reveals a Soft Boundary between Ordered and Disordered Regions

Melissa N Webby, Nicole Herr, Esther MM Bulloch, Michael Schmitz, Jeremy R Keown, David C Goldstone, Richard L Kingston

Viruses, vol. 13, MDPI, 2021, p. 1737

Structural Analysis of the Menangle Virus P Protein Reveals a Soft Boundary between Ordered and Disordered Regions. Viruses 2021, 13, 1737

MN Webby, N Herr, EMM Bulloch, M Schmitz, JR Keown, DC Goldstone, RL Kingston

s Note: MDPI stays neu-tral with regard to jurisdictional claims in~…, 2021

Structure of an H3N2 influenza virus nucleoprotein

Michael L Knight, Haitian Fan, David LV Bauer, Jonathan M Grimes, Ervin Fodor, Jeremy R Keown

Acta Crystallographica Section F: Structural Biology Communications, vol. 77, International Union of Crystallography, 2021, pp. 208--214

The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme

Alexander P Walker, Haitian Fan, Jeremy R Keown, Michael L Knight, Jonathan M Grimes, Ervin Fodor

Nucleic acids research, vol. 49, Oxford University Press, 2021, pp. 13019--13030

Host ANP32A mediates the assembly of the influenza virus replicase

Lo{\"\i}c Carrique, Haitian Fan, Alexander P Walker, Jeremy R Keown, Jane Sharps, Ecco Staller, Wendy S Barclay, Ervin Fodor, Jonathan M Grimes

Nature, vol. 587, Nature Publishing Group UK London, 2020, pp. 638--643

Parallel evolution in the emergence of highly pathogenic avian influenza A viruses

Marina Escalera-Zamudio, Michael Golden, Bernardo Gutiérrez, Julien Thézé, Jeremy Russell Keown, Loic Carrique, Thomas A Bowden, Oliver G Pybus

Nature Communications, vol. 11, Nature Publishing Group UK London, 2020, p. 5511

The RING domain of TRIM69 promotes higher-order assembly

Jeremy R Keown, Joy Yang, Moyra M Black, David C Goldstone

Acta Crystallographica Section D: Structural Biology, vol. 76, International Union of Crystallography, 2020, pp. 954--961

A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Yunyuan Sun, Jeremy R Keown, Moyra M Black, Charl{\`e}ne Raclot, Nicholas Demarais, Didier Trono, Priscilla Turelli, David C Goldstone

Journal of molecular biology, vol. 431, Academic Press, 2019, pp. 2511--2527

A method for analyzing the composition of viral nucleoprotein complexes, produced by heterologous expression in bacteria

Melissa N Webby, Matthew P Sullivan, Kavestri M Yegambaram, Mazdak Radjainia, Jeremy R Keown, Richard L Kingston

Virology, vol. 527, Academic Press, 2019, pp. 159--168

Crystal structure of protein tyrosine phosphatase-2 from Cydia pomonella granulovirus

Guangmei Huang, Michael R Oliver, Jeremy R Keown, David C Goldstone, Peter Metcalf

Acta Crystallographica Section F: Structural Biology Communications, vol. 75, International Union of Crystallography, 2019, pp. 233--238

Design, synthesis, and biological evaluation of novel indoles targeting the influenza PB2 cap binding region

David C McGowan, Wendy Balemans, Werner Embrechts, Magali Motte, Jeremy R Keown, Christophe Buyck, Jordi Corbera, Mario Funes, Laura Moreno, Ludwig Cooymans, others

Journal of medicinal chemistry, vol. 62, American Chemical Society, 2019, pp. 9680--9690

Structure of a hyperthermostable dimeric archaeal Rubisco from Hyperthermus butylicus

Rudranuj Bundela, Jeremy Keown, Serena Watkin, Frederick Grant Pearce

Acta Crystallographica Section D: Structural Biology, vol. 75, International Union of Crystallography, 2019, pp. 536--544

Structure of a hyperthermostable dimeric archaeal Rubisco from Hyperthermus butylicus

Rudranuj Bundela, Jeremy Keown, Serena Watkin, Frederick Grant Pearce

Acta Crystallographica Section D: Structural Biology, vol. 75, International Union of Crystallography, 2019, pp. 536--544

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

Haitian Fan, Alexander P Walker, Lo{\"\i}c Carrique, Jeremy R Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, others

Nature, vol. 573, Nature Publishing Group UK London, 2019, pp. 287--290

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5$\alpha$ and mammalian autophagy-related ATG8 proteins

Jeremy R Keown, Moyra M Black, Aaron Ferron, Melvyn Yap, Michael J Barnett, F Grant Pearce, Jonathan P Stoye, David C Goldstone

Journal of Biological Chemistry, vol. 293, Elsevier, 2018, pp. 18378--18386

An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

Timothy M Ryan, Jill Trewhella, James M Murphy, Jeremy R Keown, Lachlan Casey, F Grant Pearce, David C Goldstone, Kelan Chen, Zhenyao Luo, Bostjan Kobe, others

Journal of applied crystallography, vol. 51, International Union of Crystallography, 2018, pp. 97--111

Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly

Serena AJ Watkin, Jeremy R Keown, Eric Richards, David C Goldstone, Sean RA Devenish, F Grant Pearce

Biochemical Journal, vol. 475, Portland Press Ltd., 2018, pp. 137--150

The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases

Jully Pinheiro, Jacob Biboy, Waldemar Vollmer, Robert P Hirt, Jeremy R Keown, Anastasiia Artuyants, Moyra M Black, David C Goldstone, Augusto Simoes-Barbosa

MBio, vol. 9, American Society for Microbiology 1752 N St., NW, Washington, DC, 2018, pp. 10--1128

Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5$\alpha$

Jeremy R Keown, Joy X Yang, Jordan Douglas, David C Goldstone

Scientific reports, vol. 6, Nature Publishing Group UK London, 2016, p. 26837

Crystal structure of the Trim5$\alpha$ Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface

Jeremy Russell Keown, David Charles Goldstone

Journal of structural biology, vol. 195, Academic Press, 2016, pp. 282--285

Characterization of spinach ribulose-1, 5-bisphosphate carboxylase/oxygenase activase isoforms reveals hexameric assemblies with increased thermal stability

Jeremy R Keown, Frederick Grant Pearce

Biochemical Journal, vol. 464, Portland Press Ltd., 2014, pp. 413--423

Small oligomers of ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase are required for biological activity

Jeremy R Keown, Michael DW Griffin, Haydyn DT Mertens, F Grant Pearce

Journal of Biological Chemistry, vol. 288, Elsevier, 2013, pp. 20607--20615

Structure of the Nipah virus polymerase complex

Esra Bal\i{}k\c{c}\i{}, Franziska G\"{u}nl, Lo\"{\i}c Carrique, Jeremy R Keown, Ervin Fodor, Jonathan M Grimes

The EMBO Journal, vol. 0, 0, pp. 1-24